Last bead - difficult not only due to largest drop?

I just had this thought recently as I continue my taper and life is coming back faster than ever. Any expert opinions welcomed. My last bead will be an occupancy drop of 4.1% in the Thalamus. This is the largest occupancy % difference throughout the entire course of my taper. I'm wondering if my body will respond intensely to the last drop not only for this reason, though. I'm considering hypothetically that, after forming a dependency, the body can take one bead and "milk" it, so that when that bead is no longer there, it is more intense than what just this 4.1% metric depicts. I know this might not be very worthwhile for me to think about so much, but I'm just trying to prepare myself for the end of my taper. I know I might need to hold some as I get closer to the end.