Vortioxetine

Posted in:

Prozac (Fluoxetine)Support Trintellix (Vortioxetine)

November 12, 2026

What are your thoughts on Vortioxetine? I’m going through severe withdrawal symptoms after kindling and cold turkey Fluoxetine (Prozac). My symptoms are akathisia, burning, low mood, agitation, lack of sleep etc. I was suggested Vortioxetine by some doctor. After my experience with Fluoxetine I wouldn’t rush into anything, but was just wondering if any of you have any experience or thoughts regarding this drug? This same doctor also recommended loprazolam 1mg. Thank you.

2008 - Fluoxetine (Prozac) 20mg - cold turkey 2009.
2011 - Fluoxetine 20mg, dose up to 40mg for 3 months then back to 20mg - tapered 2013.
2021 - Fluoxetine 20mg for several months then down to 20mg every other day - tapered off May 2026.
July 2026 Fluoxetine prescribed 10mg - stayed on it for 19 days only, due to severe adverse reaction then was advised by GP to Cold turkey.
Buspirone 5mg 3x a day - a week only due to severe reaction stopped after one week.
Not on medication at the moment.

5 Replies

Julesok4h ago

Mirtazapine

@RO are you still going through WD now? Not familiar with vortioxatine .

Mirtazapine — 7.5 — 4 years but only used as a sleeping med on and off . My mistake!

⭐

Catina4h ago

Community AnchorEffexor

"What are your thoughts on Vortioxetine?" — @RO

My thoughts are this: Doctors always want to add another drug when people are going through withdrawal from psychiatric drugs. Many times additional drugs add further fuel to an already raging fire from a nervous system that is destabilized and highly sensitized. Generally speaking, most doctors do not understand anything about safe deprescribing or how to handle withdrawal-related issues. Many times peoples' withdrawal gets misdiagnosed, which leads to further drugging and a worsening of symptoms and the iatrogenic injury. The biggest healer I've seen is keeping things as simple as possible and allowing time to do its healing. It's safe, it's simple, and it works.

Venlafaxine (tapering) - Current dose 16.64 mg
Trazodone - 50 mg
Synthroid - 25 mcg

“Your brain and body know how to heal. Trust the process and keep going.”

Please Note: I am not a healthcare professional. Any advice given is based on personal experience and that of others in the lay withdrawal community.

RO2h ago

@Catina Thank you. That’s what I thought too. I’m now very cautious especially to those doctors who don’t understand withdrawal. I know some people use Benzodiazepines in withdrawal, but there’s no guarantee that it would work for everyone and there’s also a risk of paradoxical effects, right?

RO2h ago

"are you still going through WD now? Not familiar with vortioxatine ." — @Julesok

Yes I am. Three months going.

⭐

Catina1h ago

Community AnchorEffexor

"I know some people use Benzodiazepines in withdrawal, but there’s no guarantee that it would work for everyone and there’s also a risk of paradoxical effects, right?" — @RO

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