Hepatotoxicity

May 10, 2026··

Some bad news. My liver has fat buildup due to non-alcoholic causes. This has gotten much worse over the last months and years. I am feeling pretty good and would prefer to hold my meds for an extended period of time. But I cannot, as some of my meds can significantly contribute to my fatty liver disease. So my question is whether you have any input on meds causing or contributing to fatty liver. I may have to drop depakote by as much as 40% or 50% at a time, because not only smaller pills in the extended form are completely unavailable, but also this should probably not be taken by people with any advanced liver problems. There is almost no pain and the disease is easily reversible - if properly treated. There is no news yet on whether there is fibrosis or which stage it is.

Prozac — 40 mg — 6 months — holding | Zyprexa — 20 mg — 6 years — holding | Depakote — 600 mg — 8 months — **tapering** | Buspirone — 20 mg — 8 months — holding | with clinician
"If life is painful, start a rebellion and make it good."

3 Replies

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CatinaMay 10

Community AnchorEffexor

Hi Wolf, I'm really sorry to hear this. 😟 I did a bit of research, and evidently both Zyprexa and Depakote can cause issues. Depakote especially has been linked to fatty changes in the liver. I'll include some information below: https://www.ncbi.nlm.nih.gov/books/NBK548842/?utm_source=chatgpt.com https://pmc.ncbi.nlm.nih.gov/articles/PMC8516847/?utm_source=chatgpt.com

Venlafaxine (tapering) - Current dose 17.92 mg
Trazodone - 50 mg
Levothyroxine - 25 mcg

“Your brain and body know how to heal. Trust the process and keep going.”

Please Note: I am not a healthcare professional. Any advice given is based on personal experience and that of others in the lay withdrawal community.

WolfMay 12

Community AnchorProzac · researching

@Catina My notifications show me two replies to this thread, but there are no replies visible. I'm not sure what is going on.

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CatinaMay 12

Community AnchorEffexor

"My notifications show me two replies to this thread, but there are no replies visible. I'm not sure what is going on."

There could still be some bugs that need to be worked out. @Based Psychiatrist was making sure that tagging notifications worked, but it could have thrown something off. I'm sure he'll see this post and investigate things. Thanks Wolf!

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