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Tapering: Zoloft

reinstated

2 posts

Southern California, US

Hi, I'm Dolllie

July 29, 2026··
Hi, was on 50mg zoloft for 30 yrs. Began 6mo taper 9/2025, 50mg to 6.25mg, completely stopping zoloft 3/1/26. Big mistake, I wasn't prepared for what followed... protracted SSRI withdrawal: Massive Anxiety, CNS issues, autonomic nervous system issues, rage, insomnia, 'freezing' episodes and more. Early 6/26 BP spiked... added Buspar and trazadone. Helped tremendously with anxiety. Protected my heart. But then the pain started. All my arthritic joints with arthritis or previous injuries (67 yr old woman) were not only stiff seemingly over night, but now I instantly suffered hyperalgesia, pain... all the time. Towards end of June 2026 finally found NP willing and seeming capable of helping me reintroduce zoloft at 2.0mg/day to then begin hyperbolic taper off of zoloft. For 18 days I dosed 2.0mg liquid zoloft. Then I finally said I was done. I simply couldn't continue this current hell I've been in. So increased to 5.0mg zoloft 6 days ago. Initially for 4 days I began to feel like myself again... less agitation, sleeping a bit better, pain reduced, brain fog started to lift. Then BAM! Pain is back! Mind is not functioning. Muscle cramps waking me from sleep, etc. I'm not even sure if going back on a therapeutic dose of zoloft is going to work for me. I came across this forum by chance. Anyone have a similar experience?

Zoloft — 5mg — 6 days — reinstated | BuSpar — 7.5 mg twice daily — 7 weeks — holding | Vistaril / Atarax — 10mg — 6 days — holding | with clinician

3 Replies

Catina
Catina1mo ago
Community AnchorEffexor
Hi @Dolllie, and welcome! I'm sorry to hear about your struggles with tapering, withdrawal, and physical pain. Withdrawal can hit extra hard when you've been on a drug for decades and then taper too fast. Even at "low" doses these drugs have tremendous effects on the brain. Some people do find that reinstating a very small amount can reduce withdrawal symptoms, but you don't want to reinstate at too high of a dose. Here is some information about Reinstatement: https://taper.community/thread/affd8e83-2361-4973-8f07-76d16744448a https://taper.community/resources/blog/reinstating-after-failed-cold-turkey Muscle and joint pain are quite common in withdrawal: https://taper.community/thread/4b24f178-40ff-4176-bff3-44b116e205d4 https://taper.community/resources/blog/muscle-pain-and-tension-during-withdrawal I really hope things improve soon. Let us know if you have any further questions. Catina 💜

Venlafaxine (tapering) - Current dose 17.92 mg
Trazodone - 50 mg
Levothyroxine - 25 mcg

“Your brain and body know how to heal. Trust the process and keep going.”

Please Note: I am not a healthcare professional. Any advice given is based on personal experience and that of others in the lay withdrawal community.

D
Dolllie24d ago
WelcomerZoloft · reinstated
Hi, I’ve maintained 5mg Zoloft for 5 weeks now. I actually feel pretty human again. I guess the important thing is this level of medication has caused most of the debilitating withdrawal symptoms to end: little to no anxiety, pain or rage. My mood still fluctuates, pretty quickly, and I easily fly off the handle at my husband; I still have joint stiffness, especially in my hands in the morning, but that is also improving; occasionally wake during night from foot and or leg cramps. I have my next med appointment in 2 days, and expect to increase the Zoloft to 10mg/day. I’ve come to a place of acceptance that after 30 years of putting a drug in my body, my body now needs it to function ‘normally’, whatever that may mean. Bottom line, for 6 months my life was hell, with anxiety, rage and then pain. I’m 67 years old and don’t want to spend any more of my life like that. I now hope & believe I can find a new lower dose of Zoloft to stabilize my body, minimizing side effects, and be ok. That is my goal. I still find it very distressing that mental health drugs are so rampantly prescribed without proper education, including length of use, discontinuation, etc. Thinking of my own situation when prescribed Zoloft, I was desperate for symptom relief from depression. Maybe someone suggesting I’d be on this drug forever would have made me more resistant to trying it. I don’t know, but over 30 years of use, no medical clinician ever questioned its use. This should be concerning to everyone on any drug. I’m thankful for this forum for people like me looking for support with tapering off psychiatric drugs. It’s very needed. Good luck to all.

Zoloft — 5mg — 6 days — reinstated | BuSpar — 7.5 mg twice daily — 7 weeks — holding | Vistaril / Atarax — 10mg — 6 days — holding | with clinician

Catina
Catina24d ago
Community AnchorEffexor
I'm relieved you're doing better now Dollie! I was very concerned about you. Please treat anymore updoses with caution though. Going from 5 mg to 10 mg is a big jump. If you feel like you're stabilizing at the 5 mg, you can always just hold there until things improve even more. When the CNS is destabilized and extra sensitive, sometimes more of something isn't necessarily better. I agree with your concerns about these drugs. Too many people are put on them with no exit plan. Keep us updated on how you're doing! 💕

Venlafaxine (tapering) - Current dose 17.92 mg
Trazodone - 50 mg
Levothyroxine - 25 mcg

“Your brain and body know how to heal. Trust the process and keep going.”

Please Note: I am not a healthcare professional. Any advice given is based on personal experience and that of others in the lay withdrawal community.

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